What is a glass-lined reactor and why is it used in pharmaceuticals?

A glass-lined reactor has a carbon steel body coated with borosilicate glass enamel on the inner surface. The glass provides exceptional corrosion resistance, an inert non-porous surface that prevents contamination, and is compatible with a wide range of chemical solvents and APIs.

What is the difference between a batch reactor and a CSTR?

A batch reactor processes one charge at a time u2014 filling, reacting, draining, and cleaning between batches. A CSTR (Continuous Stirred Tank Reactor) operates continuously with simultaneous reactant feed and product withdrawal, giving consistent output without downtime.

What certifications does a cGMP pharmaceutical reactor require?

cGMP reactors require material test reports (MTR), surface finish reports (Ra u2264 0.4 u00b5m), weld inspection reports, hydrostatic test certificates, instrument calibration certificates, and FAT documentation. ASME and PED certification may also be required for pressurised systems.

What pressures can high-pressure autoclaves handle?

Industrial high-pressure autoclaves handle operating pressures from 10 bar up to 350 bar and temperatures up to 350u00b0C, used for hydrogenation, polymerisation, hydrothermal synthesis, and supercritical extraction.

Chemical Reactor Types for Pharmaceutical & Fine Chemical Manufacturing in India

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Chemical Reactor Types for Pharmaceutical & Fine Chemical Manufacturing in India

A comprehensive guide to jacketed batch reactors, glass-lined reactors, CSTR continuous reactors, and high-pressure autoclaves for pharmaceutical API, fine chemical, and specialty chemical manufacturing in India.

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